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Typical
applications of Polaris technologies for bulk pharmaceutical
industry:
- synthesis plants for intermediates
and finished products
- fermentation plants
- continuous distillation
- batch distillation
- liquid/liquid extraction
- vent gas treatment with cryogenic condensation
- vent gas treatment with adsorption on activated carbons
or resins
- integrated systems for process waste water treatment
- solvent recovery
- drying of organic products
- incineration of solid/liquid/gas wastes
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Special applications:
- Spray drying of pharmaceutical
products, dissolved in organic solvents, under inert atmosphere
and in closed circuit, in order to obtain the amorphous structure
of the dried product, the quantitative recovery of the used
solvent, the compliance with law limits for emissions in atmosphere.
- Drying of organic products
in inert atmosphere, realised with closed circuit, with integrated
solvent recovery and final treatment of excess emission from
drying circuit for quantitative removal of the contaminants.
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Plant for syntesis of antibiotics
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Polaris is available for modification
or integration of conventional existing plants, that work
with air in open or closed loop (improving product quality
and safety of drying process), or already working with inert
atmosphere.
- Distillation, during or at
end of reaction, under pressure or vacuum, to selectively
separate from reactor mixture one or more volatile compounds
(liquid or gases produced by the reaction, solvents, excess
reactants, etc.), leaving unaltered (qualitatively and quantitatively)
the other components of the mixture, and obtaining the direct
recovery of the separated compounds with quality characteristics
that can permit their reuse.
- Synthesis reactions with organic
solvents at low temperatures, close to melting point of the
solvent itself, even characterised by high reaction enthalpy,
in order to get higher quality and yield even working with
lower reaction volumes, thus improving the process productivity.
Polaris can modify and integrate existing reaction plants
in order to achieve the lowest possible temperatures.
- Birch reduction of aromatic
rings in liquid ammonia. Polaris has designed and supplied
a completely automated plant, successfully working since years,
with a 14 m3 reactor, where the complete recovery of ammonia
in liquid and anhydrous form for successive reuse is carried
out, using the proprietary internal reflux column.
- Electrochemical reactions
with water insoluble organic solvents. Polaris has designed
and supplied a special reactor for electrochemical cloration
of pharmaceutical intermediates soluble in non-polar organic
solvents, with which high conversion yields and product purities
have been achieved.
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Methanol recovery
plant from mother liquors
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- Distillation of particularly
complex solvent mixtures, residual from production processes,
in order to get single high purity fractions to be reused
or to be sold with economical benefit. For this purpose Polaris
patented technologies are adopted, combined with conventional
techniques for mixture pretreatment and liquid extraction.
- Treatment of waste water non
acceptable for conventional chemical or biological methods,
realised with combined system for evaporation and reusable
low pressure steam production, incineration of the more volatile
organic fractions and concentrated residues, organic and inorganic,
associated to other treatments for integral water recovery,
thus realising the "Zero Discharge Ecology".
- Purification of highly contaminated
water with organic fractions, more or less volatile than water,
in order to obtain water that can be discharged to public
sewer or to superficial water, and a concentrated residue
to be disposed for incineration.
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Such treatment, limited to the
more "difficult" fractions, is normally associated
to other existing purification techniques in order to reduce
operating costs, to achieve a global minor environmental impact,
and to allow a different use of the waste waters not possible
in other way because of the presence of some residual contaminants.
- Treatment and purification
of gas effluents coming from productions equipment vents or
from central collection headers, using proprietary patented
technologies of cryogenic condensation/solidification of pollutants,
or alternatively adsorption on activated carbons (or macroporous
resins) regenerated with nitrogen in closed loop. The technology
is chosen based on the pollutants characteristics, their concentration
in the effluents, the total emission flowrate, the optimal
reduction of investment and operating costs. The treatment
allows the recovery of solvents and other interesting compounds
from economical point of view, pure or in form of mixture
to be submitted to further fractionation techniques in order
to be reused or sold.
- Incineration of organic liquid
and semi-solid wastes containing chloro-derivatives, also
associated to the combustion of polluted gaseous emissions,
with multistage purification of flue gases. The technology
for incineration and consequent flue gas stabilisation carried
out in the Polaris plant, as it results by rigorous analyses
made, allows to keep the dioxin level below 0,01 ng/Nm3, one
tenth of the limit allowed by the most strict legislation.
- Improvement of mass transfer
in aerobic industrial fermentation processes, realised with
the use of additional oxygen, and eventual modification of
stirring system.
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Polaris Srl - R1.0 - June 2005 |
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