Typical applications of Polaris technologies for bulk pharmaceutical industry:

- synthesis plants for intermediates and finished products
- fermentation plants
- continuous distillation
- batch distillation
- liquid/liquid extraction
- vent gas treatment with cryogenic condensation
- vent gas treatment with adsorption on activated carbons or resins
- integrated systems for process waste water treatment
- solvent recovery
- drying of organic products
- incineration of solid/liquid/gas wastes

 

Special applications:

- Spray drying of pharmaceutical products, dissolved in organic solvents, under inert atmosphere and in closed circuit, in order to obtain the amorphous structure of the dried product, the quantitative recovery of the used solvent, the compliance with law limits for emissions in atmosphere.

- Drying of organic products in inert atmosphere, realised with closed circuit, with integrated solvent recovery and final treatment of excess emission from drying circuit for quantitative removal of the contaminants.

Plant for syntesis of antibiotics

 

Polaris is available for modification or integration of conventional existing plants, that work with air in open or closed loop (improving product quality and safety of drying process), or already working with inert atmosphere.

- Distillation, during or at end of reaction, under pressure or vacuum, to selectively separate from reactor mixture one or more volatile compounds (liquid or gases produced by the reaction, solvents, excess reactants, etc.), leaving unaltered (qualitatively and quantitatively) the other components of the mixture, and obtaining the direct recovery of the separated compounds with quality characteristics that can permit their reuse.

- Synthesis reactions with organic solvents at low temperatures, close to melting point of the solvent itself, even characterised by high reaction enthalpy, in order to get higher quality and yield even working with lower reaction volumes, thus improving the process productivity. Polaris can modify and integrate existing reaction plants in order to achieve the lowest possible temperatures.

- Birch reduction of aromatic rings in liquid ammonia. Polaris has designed and supplied a completely automated plant, successfully working since years, with a 14 m3 reactor, where the complete recovery of ammonia in liquid and anhydrous form for successive reuse is carried out, using the proprietary internal reflux column.

- Electrochemical reactions with water insoluble organic solvents. Polaris has designed and supplied a special reactor for electrochemical cloration of pharmaceutical intermediates soluble in non-polar organic solvents, with which high conversion yields and product purities have been achieved.

 

 

Methanol recovery plant from mother liquors

- Distillation of particularly complex solvent mixtures, residual from production processes, in order to get single high purity fractions to be reused or to be sold with economical benefit. For this purpose Polaris patented technologies are adopted, combined with conventional techniques for mixture pretreatment and liquid extraction.

- Treatment of waste water non acceptable for conventional chemical or biological methods, realised with combined system for evaporation and reusable low pressure steam production, incineration of the more volatile organic fractions and concentrated residues, organic and inorganic, associated to other treatments for integral water recovery, thus realising the "Zero Discharge Ecology".

- Purification of highly contaminated water with organic fractions, more or less volatile than water, in order to obtain water that can be discharged to public sewer or to superficial water, and a concentrated residue to be disposed for incineration.

 

Such treatment, limited to the more "difficult" fractions, is normally associated to other existing purification techniques in order to reduce operating costs, to achieve a global minor environmental impact, and to allow a different use of the waste waters not possible in other way because of the presence of some residual contaminants.

- Treatment and purification of gas effluents coming from productions equipment vents or from central collection headers, using proprietary patented technologies of cryogenic condensation/solidification of pollutants, or alternatively adsorption on activated carbons (or macroporous resins) regenerated with nitrogen in closed loop. The technology is chosen based on the pollutants characteristics, their concentration in the effluents, the total emission flowrate, the optimal reduction of investment and operating costs. The treatment allows the recovery of solvents and other interesting compounds from economical point of view, pure or in form of mixture to be submitted to further fractionation techniques in order to be reused or sold.

- Incineration of organic liquid and semi-solid wastes containing chloro-derivatives, also associated to the combustion of polluted gaseous emissions, with multistage purification of flue gases. The technology for incineration and consequent flue gas stabilisation carried out in the Polaris plant, as it results by rigorous analyses made, allows to keep the dioxin level below 0,01 ng/Nm3, one tenth of the limit allowed by the most strict legislation.

- Improvement of mass transfer in aerobic industrial fermentation processes, realised with the use of additional oxygen, and eventual modification of stirring system.


© Polaris Srl - R1.0 - June 2005
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